Foster Kennedy's Syndrome

Authored by on
This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.

This page has been archived. It has not been updated since 23/05/2011. External links and references may no longer work.

Synonyms: Kennedy's phenomenon; Gowers-Paton-Kennedy syndrome

Foster Kennedy's syndrome (FKS) is a rare neurological sign first described in 1911 by Robert Foster Kennedy.[1, 2] He was a British neurologist, who spent the majority of his working life in America (1884-1952). It consists of:

Pseudo-FKS has also been described, in which there is unilateral optic disc swelling with contralateral optic atrophy in the absence of an intracranial mass.This occurs typically due to bilateral sequential optic neuritis or ischaemic optic neuropathy.[3] A case secondary to pachymeningitis (inflammation of the dura mater) has also been reported.[4]

It is most commonly caused by a tumour on the inferior surface of the frontal lobe. This is usually an olfactory groove meningioma or a medial third sphenoidal wing meningioma.

It has also been reported as a consequence of:

  • A metastatic cerebral tumour.[5]
  • Arteriovenous malformation, in which chronic venous hypertension was the likely aetiology.[6]
  • Juvenile nasopharyngeal angiofibroma (a rare benign tumour of the nasopharynx that occurs in adolescent boys with epistaxis and nasal obstruction).[7]

A review of the 36 previously reported cases of FKS revealed that only eight (22%) of the cases satisfied Foster Kennedy's original hypothesis for the pathogenesis of his syndrome. 12 cases (33%) were probably caused by bilateral optic nerve compression.[8] The authors conclude that as more sophisticated imaging permits earlier and more precise diagnosis, future cases of FKS caused by a mass will probably be found to result from bilateral direct optic nerve compression.

These include:

Both depend on the underlying cause.

Further reading and references

  • ; Foster Kennedy Syndrome in a Case with Retinitis Pigmentosa. Ophthalmic Surg Lasers Imaging. 2010 Mar 9:1-3. doi:

  1. Kennedy F; Retrobulbar neuritis as an exact diagnostic sign of certain tumors and abscesses in the frontal lobe. American Journal of the Medical Sciences, Thorofare, N.J., 1911, 142: 355-368

  2. ; Neurosurgery 100 years ago: the Queen Square letters of Foster Kennedy. Neurosurgery. 2005 Oct57(4):797-808

  3. ; Pseudo-Foster Kennedy Syndrome due to unilateral optic nerve hypoplasia: a case J Med Case Reports. 2008 Mar 182:86.

  4. ; Pachymeningitis with pseudo-Foster Kennedy syndrome. Am J Ophthalmol. 2000 Oct130(4):535-7.

  5. ; A case of Foster Kennedy syndrome without frontal lobe or anterior cranial fossa involvement. Neurosurg Rev. 199215(2):139-42.

  6. ; An atypical case of Foster Kennedy syndrome. Interv Neuroradiol. 2010 Dec16(4):429-32. Epub 2010 Dec 17.

  7. ; Juvenile nasopharyngeal angiofibroma presenting as Foster Kennedy Syndrome. Ethiop Med J. 2001 Jul39(3):251-60.

  8. ; Bilateral optic nerve compression as a mechanism for the Foster Kennedy syndrome. Ophthalmology. 1989 Dec96(12):1793-8.

i have spasm permanently in my legs right eye and left arm with weakness. The rest of my body has spasm that comes and goes regularly i get pain in my body all the time and i have a permanent burning...

Nj72
Health Tools

Feeling unwell?

Assess your symptoms online with our free symptom checker.

Start symptom checker
продажа виагры

покрывало на кровать купить

https://monaliza.kiev.ua