Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.
There are three reasons why athletes and sportspeople may take drugs:
- As medication for disease: they are as entitled to treatment of a medical condition as anyone else but both the competitor and the doctor must be aware of the rules about banned substances. Failure to heed them can have serious consequences. An athlete could receive either a temporary or permanent ban from competing in that sport. If the doctor is at fault, there is potential for litigation irrespective of whether the individual is an amateur or professional competitor.
- To enhance performance: in doing so this could give an unfair advantage. The GMC's stance on this is unequivocal:
Doctors who prescribe or collude in the provision of drugs or treatment with the intention of improperly enhancing an individual's performance in sport would be contravening the GMC's guidance and such actions would usually raise a question of a doctor's continued registration. This does not preclude the provision of any care or treatment where the doctor's intention is to protect or improve the patient's health.
- As recreational drugs: eg, cannabis is a banned substance even though it is not considered a performance-enhancing drug. The authorities say that it is necessary to take such steps, as athletes and sportspeople are role models for young people and hence should not take illicit drugs. However, they do not suggest how young people would know that their heroes take drugs if they were not tested and positive results made public.
- All elite athletes competing at international level and professional sportspeople are likely to be routinely tested. However, testing may go down to much lower levels and include young competitors. Sometimes testing may be anticipated. It is common practice to test all who have won medals in major events but random drug testing can also take place. Elite athletes may also be visited by representatives from their governing body for out-of-season testing.
- Some drugs are permissible when a sportsperson is not competing but not permissible during competition. Others, such as anabolic steroids are banned at all times.
- Some drugs are banned in some sports but not in others. Banned substances can include alcohol and caffeine above a certain level. Beta-blockers would impair performance of an endurance athlete but suppression of tremor gives unfair advantage in shooting events. It may be possible to obtain guidance from the sport's website. Several useful sites are listed at the end of this article.
- Drug testing does not apply simply to sports such as athletics and football but may include snooker, bridge and chess played at the highest levels.
Therapeutic use exemption
If a doctor believes that there is a good reason why his patient needs a banned substance, it is possible to issue a Therapeutic Use Exemption (TUE) certificate - eg, the one used for football is found at the FIFA website.They may be temporary for a single spell of illness or of longer duration. They must be issued in good faith, stating that alternative medication is inappropriate - for example, if a snooker player has hypertension, does he really need a beta-blocker?
The problems faced by a doctor may be for relatively minor treatments such as decongestants, analgesics and medication for asthma. As mentioned above, some drugs are permissible in some sports and not in others. Some are permissible out of competition but not whilst competing.
The World Anti-Doping Agency (WADA) produces a full list of prohibited drugs every year.
Doctors need to be aware of the possibility that patients may use an element of deceit to acquire prescriptions for substances that they know they should not have.
- Athletes often sustain injuries and analgesics may be appropriate. Non-steroidal anti-inflammatory drugs (NSAIDs) are the group of choice and are always permissible, as is paracetamol.
- Opiate-related analgesics are more problematic. Codeine is not on the WADA list of banned substances and combinations such as co-codamol appear acceptable. It is the stronger narcotic agents that are banned. However, screening does not always differentiate adequately between the various narcotic- or codeine-related compounds and they are best avoided.
- Sometimes an athlete will ask the doctor to give an injection into an injured part to permit competition. Pain is an important warning that something is wrong and if a significant injury is pain-free this is a potentially dangerous situation. Steroid injections may also weaken ligaments and should not be given into tendons or ligaments.
The main reason for wishing to use diuretics is to produce more dilute urine so that illicit substances are not detected. For this reason they are banned. They may also be used in sports with weight categories, such as judo and weightlifting. The competitor can dehydrate, make the weight at the weigh-in and then rehydrate before the competition, as even mild dehydration can ebb fitness significantly. Jockeys have used diuretics for many years. Masking substances to hide the use of illicit drugs include probenecid and this is also banned.
- The problem of stimulants in sport reached public attention in 1960 when the Danish cyclist Knut Jenson died in the Rome Olympics and it transpired that he had been taking amfetamines.
- The problem for doctors is not usually with amfetamines, as these now have few indications but with decongestants that may be requested or bought over the counter to clear the airways of an athlete with a cold.
- Pseudoephedrine is prohibited when the concentration in the urine is >150 micrograms per millilitre. Pseudoephedrine has been moved from the prohibited list to the monitoring program (ie it is one of several drugs which can be used during competition only but which WADA is monitoring for abuse). Ephedrine is prohibited when its concentration in urine is >10 micrograms per millilitre.This probably means that 0.5% ephedrine nasal drops are safe.
- Saline nasal drops are certainly safe and allowed but less effective. If a pharmacological agent is required, an anticholinergic such as ipratropium spray may be used.
- Beta-2 agonists are banned substances but they may be used if delivered by inhaler to a patient with asthma and a TUE is issued.
- Corticosteroids are also banned. A TUE may be issued although one might wonder whether an athlete needing such treatment would be fit to compete at top level anyway. Topical steroids are permitted.
Enhancement of oxygen transfer
For endurance events, a high haematocrit enhances performance. There are three ways to achieve this:
- Training at altitude in a low PO2 stimulates endogenous erythropoietin.
- Recombinant erythropoietin is effective, especially if combined with supplementary iron.
- Blood doping means removal of a unit of blood, perhaps 4 to 6 weeks before competition; the body replaces the lost blood and shortly before competition the blood is transfused (autologous transfusion).
Of these three techniques, only altitude training is legal. Substances to enhance oxygen uptake and haemoglobin substitutes are also banned. Although it was hoped that techniques to detect blood doping by autologous transfusion would be ready by the 2012 Olympics, this did not transpire. Research on this and on other methods of detecting illicit methods of oxygen transfer enhancement are ongoing.[4, 5]
- Anabolic steroids are a generic term for male hormones. The idea behind their abuse in sport is that they promote muscle growth and protein synthesis. However, abuse also has side-effects such as cardiomyopathy, atherosclerosis, hypercoagulopathy, hepatic dysfunction and psychiatric and behavioural disturbances.[6, 7]They may be used for hypogonadism or diseases such as aplastic anaemia but such people are unlikely to compete at an elite level.
- In the 1970s, athletes would take synthetic androgens such as nandrolone and these are easy to detect without any controversy. A much more difficult problem occurs when an endogenous substance such as testosterone is taken. The ratio of testosterone to dehydroepiandrosterone (DHEA) is usually about 1:1 or 2:1. A similar ratio is expected in women. If it is over 4:1 then exogenous testosterone is likely. Some men appear to have naturally high ratios but a radiocarbon test can detect synthetic testosterone. New ways are being developed to detect metabolites of androstenedione, testosterone and dihydrotestosterone abuse.
- Female hormones also have anabolic effects, although not as marked as male hormones. Athletes who return to training after pregnancy often find that they are stronger than they were before. Oral contraceptives are permitted substances and may well be desirable. They tend to reduce menstrual loss and hence any tendency to iron deficiency. As well as making menstruation more tolerable, they can be used to adjust its timing so that the competitor is not premenstrual or menstruating during an important event. Their value as a contraceptive is also appreciated.
- Other banned substances include tibolone, which has some anabolic effect, and anti-oestrogens including the selective oestrogen receptor modulators (SERMs) and aromatase inhibitors. If there are genuine reasons to prescribe such drugs, a TUE can be issued.
New illicit performance-enhancing agents are being developed all the time. One of the most recent is peroxisome proliferator-activated receptor-delta agonists termed GW1516. It is a constant battle to develop analytical techniques which can detect these substances. In the case of GW1516, mass spectrometry is being used for this purpose.
New trends in hormone abuse
The chemicals that we tend to think of as anabolic (the male hormones described above) are not the only ones with anabolic properties and hence other hormones may also be abused. In 1989 the Medical Commission of the International Olympic Committee (IOC) introduced the new doping class of peptide hormones and analogues. This includes:
- Human chorionic gonadotrophin (hCG) and related compounds.
- Corticotropins, including adrenocorticotropic hormone (ACTH).
- Human growth hormone (hGH), insulin-like growth factors and mechano growth factors.
- All the releasing factors of these listed hormones.
Several techniques have been developed to detect peptide hormones and analogues.
Both hCG and luteinising hormone (LH) may also be used to enhance the endogenous production of testosterone by artificial means and are prohibited in males.
Over a period of 20 years, growth hormone (GH) has been considered as a performance-enhancing drug in the world of sport. A blood test for hGH was first introduced at the 2004 Summer Olympic Games in Athens, Greece. Further tests are being developed to enhance the detection window for hGH abuse.
Recombinant GH abuse remains a major challenge and isoform assays have been developed to detect this.
GH and insulin seem to work together to control blood glucose but the role of insulin is much more profound than just glucose homeostasis. Insulin may be used to counter the hyperglycaemic effects of GH but it is also abused by bodybuilders and there are reports of severe hypoglycaemia as a result. The legal classification of insulin has been changed from 'P' (for sale in pharmacies) to 'PoM' (prescription-only medicine).
In the future, this could potentially become a new possibility for abuse as a performance enhancer in sport. WADA describes gene doping as 'the non-therapeutic use of cells, genes, genetic elements, or of the modulation of gene expression, having the capacity to improve athletic performance'. The potential for gene doping would be to inject 'normal' genes into the body to increase the functioning of a 'normal' cell. For example, genes producing insulin growth factor 1 to help muscles grow and repair.
Denying the charges
Sometimes when an athlete is found to have taken a banned substance, he or she admits to the fault but very often WILL deny ever knowingly having taken a banned substance. Cynics are unsurprised but often the athletes seem very genuine.
Maria Sharapova recently admitted testing positive for the cardiac drug meldonium but said in mitigation that she was not aware that WADA had banned it in January 2016.
In terms of physiology, elite athletes are not 'normal' people and so reference ranges for physiological substances need to be determined on their peers. A cyclist who may be burning 9,000 calories a day during competition is not a normal subject. Sprinters tend to be very muscular and have a low body fat content. Fat is important in the metabolism of steroid hormones. The people who set such standards are sufficiently well versed in sports medicine and exercise physiology that they set their standards by the normal for the group that they examine. Nevertheless, if they say that their reference range will include 99% of all those active athletes who are not taking banned substances, then 1 in 100 will fall outside that range.
Most top athletes use dietary supplements and the contents of these may not be as vigorously controlled as may be hoped. Contaminants that have been identified include a variety of anabolic androgenic steroids including testosterone and nandrolone as well as the pro-hormones of these compounds, ephedrine and caffeine. This contamination may be the result of poor manufacturing practice but there is some evidence of deliberate adulteration of products. The principle of strict liability that applies in sport means that innocent ingestion of prohibited substances is not an acceptable excuse and athletes testing positive are liable to penalties. Although it is undoubtedly the case that some athletes are guilty of deliberate cheating, some positive tests are likely to be the result of inadvertent ingestion of prohibited substances present in otherwise innocuous dietary supplements.
The position of the GMC with regard to a doctor aiding and abetting drug abuse in sport is clear. However, a doctor may be faced with a patient who admits to using anabolic steroids. He or she does not enter competitions and so is not tested. The patient wants the doctor to monitor their liver function as an early warning of any damage. What is the position? The patient will continue to take the steroids whether the doctor co-operates or not. Would it be reasonable to warn the patient of the dangers and to check liver function and lipids? This would not be endorsing the patient's action any more than a needle exchange encourages intravenous drug abuse. He or she may also benefit from the needle exchange. Is it a damage limitation exercise that can be justified?
Eliminating drugs from sport
There is a constant battle between those seeking new techniques to detect illicit use of performance-enhancing substances and those who wish to circumvent the rules. Testing is vigorous and can be unannounced and the penalties for being discovered are severe. Nevertheless, there are and always will be those who attempt to use illicit ways of enhancing performance to obtain the necessary slight edge that is required to win. From time to time illegal substances are discovered. In British sport this should not be seen as evidence of widespread abuse of drugs but evidence that a vigorous and effective system of monitoring is in place.
Some would argue that the only way to have a 'level playing field' is to lift all bans on drugs and let us push human endurance to the limit. Records have tumbled with new technologies going back to spikes and starting blocks and including modern running shoes and fibreglass poles for vaulting. Should we encourage the same with pharmacological technology? This is a false argument, as the banned substances are not without significant risk. It cannot even be argued that the athlete is free to make his or her own choice because if the opposition use drugs to gain advantage, he or she will have to do the same to be able to compete.
The 2012 London Olympics acted as a stimulus for UKAD, the UK anti-doping organisation affiliated to WADA, to strengthen its anti-doping initiatives. These were brought together under the umbrella of its 'Win Clean: Say No To Doping' campaign.
World Anti-Doping Agency
WADA was founded with the belief that 'athletes have a fundamental right to participate in doping-free sport and that doping endangers athlete health and the integrity of sport'. It serves as the independent international body responsible for co-ordinating and monitoring the global fight against doping in sport.
In recent times it has become evident that doping in sport has been far more widespread than was originally thought. Russia has recently accepted an indefinite ban from international athletic competitions due to doping offences and there are allegations of state-backed doping in China that are being investigated.[18, 19]
WADA will have its work cut out for it in the future.
Further reading and references
; The World Anti-Doping Code in sport: Update for 2015. Aust Prescr. 2015 Oct38(5):167-70. Epub 2015 Oct 1.
; Illegal performance enhancing drugs and doping in sport: a picture-based brief implicit association test for measuring athletes' attitudes. Subst Abuse Treat Prev Policy. 2014 Jan 309:7. doi: 10.1186/1747-597X-9-7.
; The athlete biological passport: an effective tool in the fight against doping. Clin Chem. 2011 Jun57(6):830-2.
; World Andi-Doping Agency (WADA)
; The evolving science of detection of 'blood doping'. Br J Pharmacol. 2012 Mar165(5):1306-15. doi: 10.1111/j.1476-5381.2011.01822.x.
; Detecting Autologous Blood Transfusion with Clinical Biomarkers, 2015.
; Anabolic-androgenic steroid dependence? Insights from animals and humans. Front Neuroendocrinol. 2008 Oct29(4):490-506. Epub 2008 Jan 3.
; National Athletic Trainers' Association position statement: anabolic-androgenic steroids. J Athl Train. 2012 Sep-Oct47(5):567-88. doi: 10.4085/1062-6050-47.5.08.
; Alternative markers for the long-term detection of oral testosterone misuse. Steroids. 2011 Nov76(12):1367-76. Epub 2011 Jul 18.
; Synthesis, Mass Spectrometric Characterization, and Analysis of the PPARdelta Agonist GW1516 and Its Major Human Metabolites: Targets in Sports Drug Testing. Methods Mol Biol. 2013952:301-12. doi: 10.1007/978-1-62703-155-4_22.
; World Anti-Doping Agency
; Clinical review: The rationale for banning human chorionic gonadotropin and estrogen blockers in sport. J Clin Endocrinol Metab. 2006 May91(5):1646-53. Epub 2006 Feb 14.
; Tracking growth hormone abuse in sport: a comparison of distinct isoform-based assays. Anal Chim Acta. 2012 Jul 6733:56-63. Epub 2012 May 3.
; Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol. 2008 Jun154(3):542-56. Epub 2008 Mar 31.
; Gene Doping: Gene delivery for Olympic victory. Br J Clin Pharmacol. 2012 Oct 22. doi: 10.1111/bcp.12010.
; The Telegraph, 2016
; Supplements and inadvertent doping - how big is the risk to athletes. Med Sport Sci. 201359:143-52. doi: 10.1159/000341970. Epub 2012 Oct 15.
; The Guardian, 2015
; BBC News, 2016
Hi I have been a prescription opiate addict for about 7 years now, relapse after relapse. I've hidden this all from my wife and have been caught a few times each time I promise to stop but end up...TrentSteel
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. high-kick.ru has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.