Heart Valves and Valve Disease

Authored by , Reviewed by Dr Adrian Bonsall | Last edited | Certified by The Information Standard

There are four common types of valve problem - mitral stenosis, mitral regurgitation, aortic stenosis and aortic regurgitation.

The heart has four chambers - two atria and two ventricles. The walls of these chambers are mainly made of special heart muscle.

Cross-section diagram of a normal heart

Anatomy of the heart

The heart is a muscular pump that pushes blood through blood vessels around the body. The heart ...

During each heartbeat both of the atria squeeze (contract) first to pump blood into the ventricles. Then both ventricles contract to pump blood out of the heart into the arteries. There are one-way valves between the atria and ventricles and also between the ventricles and the large arteries that take blood from the heart. These are:

  • The mitral valve - between the left atrium and the left ventricle.
  • The tricuspid valve - between the right atrium and the right ventricle.
  • The pulmonary valve - between the right ventricle and the pulmonary artery. (The pulmonary artery is the main artery that takes blood from the heart to the lungs to collect oxygen.)
  • The aortic valve - between the left ventricle and the aorta. (The aorta is the main artery that takes oxygen-rich blood from the heart to the body.)

The valves make sure that when the atria or ventricles contract, the blood flows the correct way through the heart and into the arteries.

See the leaflet called Anatomy of the heart. This includes details about the function of the heart and how the heart beats.

A valve that is diseased or damaged can affect the flow of blood through the heart. There are two main types of valve problem:

  • Valve stenosis. This means that the opening of the valve is narrowed and the valve does not open fully. So, there is some restriction in blood flow through the valve.
  • Valve regurgitation (sometimes called valve incompetence, or a leaky valve). This means that the valve does not close properly and there is backflow of blood through the leaky valve.

Any of the valves can be affected by these problems. However, the mitral and aortic valves are the ones that most commonly become diseased. Read more about mitral stenosis, mitral regurgitation, aortic stenosis and aortic regurgitation.

Degenerative changes

This is one of the most common causes of leaky heart valves. The structures supporting the heart valves weaken and stretch over time and this prevents the valves from closing properly.

Rheumatic heart disease

  • Rheumatic heart disease is a general term which means any heart problem which develops after having an episode of rheumatic fever.
  • Rheumatic fever is a condition which sometimes follows an infection with a germ (bacterium) called the streptococcus. Your body makes antibodies to the bacterium to clear the infection. But, in some people, the antibodies also attack various parts of the body - in particular, the heart valves. Inflammation of one or more valves may develop which can cause permanent damage and lead to thickening and scarring years later.
  • Rheumatic fever used to be common in the UK in the era before antibiotics but it is now rare. It is still quite common in some developing countries.

Other causes

Other causes of valve disease include:

Basically, the more narrow or leaky a valve is, the greater the problem is likely to be. Some minor narrowing or leakiness may cause no problems or symptoms. However:

  • If the narrowing is severe - the heart has to pump harder to get blood past the narrowing.
  • If leakiness is severe - the heart has to pump harder to pump the blood that leaks back, in addition to the normal amount of blood flowing through the heart.

In both cases, this can put a strain on the heart. There may be an increase in pressure behind the affected valve. This back pressure can cause blood and fluid to build up in the lungs or lower part of the body (depending on which valve is affected).

If symptoms do occur then they will depend on which heart valve is affected and the severity of the problem. The symptoms often develop gradually over years. However, they can develop quickly if the damage to the valve occurs quickly - for example, following a heart attack (myocardial infarction). Symptoms may include:

  • Shortness of breath. This tends to occur on exercise at first but occurs at rest if the stenosis becomes worse. This symptom is due to the congestion of blood and fluid in the lungs.
  • Fainting, dizziness or tiredness. If the amount of blood getting through to the ventricle is reduced, the output of blood from the left ventricle to the body is then reduced.
  • Chest pains (angina). This may develop if there is a reduced blood flow to the arteries that take blood to the heart muscle (the coronary arteries).
  • Fast or irregular heartbeat which you may feel as the sensation of a 'thumping heart' (palpitations).
  • Chest infections may happen more often.
  • Coughing up bloodstained sputum. This may occur due to the congestion of blood and fluid in the lungs.
  • The liver may be swollen and you may develop a swollen stomach due to fluid.
  • People with mitral stenosis may get flushed cheeks.

If rheumatic fever is the cause then symptoms often start between the ages of 20 and 50 years. (That is, 10-20 years after having have had an episode of rheumatic fever as a child.)

Various complications may develop, depending on the valve affected and the severity of the problem.

The main possible complications that may develop include the following:

  • Atrial fibrillation develops in about 4 in 10 cases. In this condition, the heart beats in a fast and irregular way. This occurs because the electrical signals in the enlarged atrium become faulty. The irregular heart rhythm can cause the sensation of a 'thumping heart' (palpitations) and make you even more breathless. See the separate leaflet called Atrial Fibrillation.
  • Heart failure may develop and gradually become more severe. This causes worsening shortness of breath, tiredness, and fluid retention in various tissues of the body. See the separate leaflet called Heart Failure.
  • Stroke. A blood clot may form within the enlarged left atrium, which does not fully empty into the ventricle with each heartbeat. A blood clot is more likely to occur if you also develop atrial fibrillation. A blood clot may travel through the heart, be carried in the bloodstream and get stuck and block a blood vessel in another part of the body. For example, it may get stuck in a blood vessel going to the brain and cause a stroke. See the separate leaflet called Stroke.
  • Endocarditis sometimes develops. This is an infection of the valve. (Damaged valves are more prone than normal valves are to infection.) Unless promptly treated, endocarditis can cause serious illness. See the separate leaflet called Infective Endocarditis.

Any treatment will depend on which valve is affected and the severity of the heart valve problem. Learn more about the treatments for mitral stenosis, mitral regurgitation, aortic stenosis and aortic regurgitation.


Mild cases may not require any regular medication. Some medicines may be prescribed to help ease symptoms, or to help prevent complications. For example:

  • Angiotensin-converting enzyme (ACE) inhibitors are medicines which help to reduce the amount of work the heart does. One may be prescribed to ease symptoms of heart failure.
  • 'Water' tablets (diuretics) usually help if you are breathless. They make the kidneys produce more urine. This gets rid of excess blood and fluid which may build up in the lungs or other parts of the body with the back pressure from the heart.
  • If you develop atrial fibrillation, several medicines can be used to slow the heart rate down. They include beta-blockers, calcium-channel blockers and digoxin. Shocking the heart with an electrical current (a procedure called cardioversion) is also an option in some people who develop atrial fibrillation as a complication.
  • Anticoagulation medication is usually advised if you develop atrial fibrillation. This helps to prevent blood clots from forming.


Surgery to stretch, repair or replace the valve may be needed in some cases. Surgical treatment has greatly improved the outlook for many cases of severe valve disease. Surgery has a very good success rate.

Further reading and references

  • ; 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease. Circulation. 2017 CIR.0000000000000503. Originally published March 15, 2017.

  • ; What is new in ACC/AHA 2017 focused update of valvular heart disease guidelines. Anatol J Cardiol. 2017 Jun17(6):421-422. doi: 10.14744/AnatolJCardiol.2017.7925.

  • ; Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology, 2017.

  • ; European Society of Cardiology (Aug 2015)

  • ; NICE Clinical Guideline (March 2008)

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